Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population

Background: The purpose of this study is to investigate the genotype and allele distribution MTHFR rs1801133 in Chinese population, analyze relationship between gene polymorphism risk childhood leukemia.
 Methods: Blood samples clinical data leukemia cases (n=1132) age-matched healthy controls (n=1053) were collected. Genotypes detected by PCR-RFLP. Logistic regression model was generated relation susceptibility chemotherapy response. 
 Results: Age, sex, BMI family history tumor comparable controls. remarkably correlated leukemia. Genotype parallel Specifically, compared with people carrying AA rs1801133, higher may occur AG+GG a younger age (<15 years) or complete remission from chemotherapy. Conclusions: has significant correlation It an important genetic reliability results requires be further validated high-quality research involving large sample size multi-center hospitals.